What is the catalog number for [KO Validated] SETD7 Rabbit pAb (APR28824N)?

The catalog number for [KO Validated] SETD7 Rabbit pAb (APR28824N) is APR28824N.

What sizes are available for [KO Validated] SETD7 Rabbit pAb (APR28824N)?

[KO Validated] SETD7 Rabbit pAb (APR28824N) is available in the following size(s): 50 µL, 100 µL, 200 µL.

How many pack sizes does [KO Validated] SETD7 Rabbit pAb (APR28824N) come in?

[KO Validated] SETD7 Rabbit pAb (APR28824N) is available in 3 different pack sizes.

Is [KO Validated] SETD7 Rabbit pAb (APR28824N) in stock?

[KO Validated] SETD7 Rabbit pAb (APR28824N) is currently made to order / not held in immediate stock. Contact us for lead time.

[KO Validated] SETD7 Rabbit pAb (APR28824N)

Product Specifications

Background

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality [KO Validated] SETD7 Rabbit pAb (APR28824N) .

Synonyms

SETD7; KMT7; SET7; SET7/9; SET9

Gene ID

80854

UniProt

Q8WTS6

Cellular Locus

Chromosome, Nucleus

Applications

WB (Human hepatocellular carcinoma cell line, Homo sapiens) IHC (Mus musculus, Rattus norvegicus) IF (Rattus norvegicus)

Dilution

WB 1:500 - 1:2000 IF 1:50 - 1:200

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 40kDa Observed MW: 48KDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=80854

Uniprot URL

https://www.uniprot.org/uniprot/Q8WTS6

AA Sequence

MDSDDEMVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGKSGPEAPEWYQVELKAFQATQQK