SMYD5 Rabbit pAb (APR26324N)

Product Specifications

Background

Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 to form trimethylated histone H4 lysine 20 (H4K20me3 which represents a specific tag for epigenetic transcriptional repression (By similarity. In association with the NCoR corepressor complex, is involved in the repression of toll-like receptor 4 (TLR4-target inflammatory genes in macrophages by catalyzing the formation of H4K20me3 at the gene promoters (By similarity. Plays an important role in embryonic stem (ES cell self-renewal and differentiation (By similarity. Promotes ES cell maintenance by silencing differentiation genes through deposition of H4K20me3 marks (By similarity. Maintains genome stability of ES cells during differentiation through regulation of heterochromatin formation and repression of endogenous repetitive DNA elements by depositing H4K20me3 marks.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SMYD5 Rabbit pAb (APR26324N) .

Synonyms

SMYD5; NN8-4AG; RAI15; RRG1; ZMYND23

Gene ID

10322

UniProt

Q6GMV2

Applications

WB (HeLa)

Dilution

WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 47kDa Observed MW: 48kDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.