AZ12799734
AZ12799734 is a selective, orally active TGFBR1 kinase inhibitor with an IC50 of 47 nM. AZ12799734 is also a pan BMP and TGFβ inhibitor[1].
Product Specifications
CAS Number
1117684-36-2
UNSPSC
12352005
Target
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/az12799734.html
Purity
98.67
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C(NC2=NC=CC(OC3=CC=C(C)N=C3C)=C2)C=C1)(N)=O
Molecular Formula
C18H18N4O3S
Molecular Weight
370.43
References & Citations
[1]Spender LC, et al. Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor β Superfamily Type 1 Receptors. Mol Pharmacol. 2019 Feb;95 (2) :222-234.|[2]Anderton MJ, et al. Induction of heart valve lesions by small-molecule ALK5 inhibitors. Toxicol Pathol. 2011 Oct;39 (6) :916-24.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ALK1; ALK2; ALK3; ALK4; ALK5; ALK6
Available Sizes
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