NCF4/p40-phox Rabbit pAb (APR24618N)
Product Specifications
Background
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI (3) kinase, which suggests its role in PI (3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Synonyms
NCF4; CGD3; NCF; P40PHOX; SH3PXD4
Gene ID
4689
UniProt
Q15080
Cellular Locus
Cytoplasm, Cytoplasmic side, Endosome membrane, Membrane, Peripheral membrane protein, cytosol
Dilution
WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Form
Liquid
Buffer
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
Calculated MW: 39kDa Observed MW: 40KDa
Storage Conditions
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality NCF4/p40-phox Rabbit pAb (APR24618N) .
Gene ID URL
https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4689
Uniprot URL
https://www.uniprot.org/uniprot/Q15080
AA Sequence
MAVAQQLRAESDFEQLPDDVAISANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYRQFHALQSKLEERFGPDSKSSALACTLPTLPAKVYVGVKQEIAEMRIPALNAYMKSLLSLPVWVLMDEDVRIFFYQSPYDSEQVPQALRRLRPRTRKVKSVSPQGNSVDRMAAPRAEALFDFTGNSKLELN
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Rabbit Monoclonal CD63 Antibody (LAMP3/8799R) [Alexa Fluor 750]](https://cdn.genprice.uk/genprice/genprice5.png)
NBP3-21029AF750 0.1 mL
Rabbit Monoclonal CD63 Antibody (LAMP3/8799R) [Alexa Fluor 750]
Ask
View Details MBS6397060-01 0.1 mL
TRAF5 (TNF Receptor-associated Factor 5, RING Finger Protein 84, RNF84, MGC:39780) (PE)
Ask
View Details 
MBS6397060-02 5x 0.1 mL
TRAF5 (TNF Receptor-associated Factor 5, RING Finger Protein 84, RNF84, MGC:39780) (PE)
Ask
View Details 