DNMT3A Rabbit pAb (APR24590N)
Product Specifications
Background
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.
Synonyms
DNMT3A; DNMT3A2; M.HsaIIIA; TBRS; DNMT3A
Gene ID
1788
UniProt
Q9Y6K1
Cellular Locus
Cytoplasm, Nucleus
Applications
WB (Human hepatocellular carcinoma cell line, HCT116, Human cells, BEL-7402, SMMC7721, Homo sapiens, Rattus norvegicus)
Dilution
WB 1:500 - 1:2000 IF 1:20 - 1:100 IP 1:50 - 1:200
Form
Liquid
Buffer
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
Calculated MW: 16kDa/81kDa/101kDa Observed MW: 110kDa
Storage Conditions
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality DNMT3A Rabbit pAb (APR24590N) .
Gene ID URL
https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1788
Uniprot URL
https://www.uniprot.org/uniprot/Q9Y6K1
AA Sequence
SVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLL
Available Sizes
Curated Selection
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