OAS1 Rabbit pAb (APR21178N)
Product Specifications
Background
This gene is induced by interferons and encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As) . This protein activates latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection and diabetes mellitus, type 1. A disease-associated allele in a splice acceptor site influences the production of the p46 splice isoform. This gene is located in a cluster of related genes on chromosome 12.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality OAS1 Rabbit pAb (APR21174N3) .
Synonyms
OAS1; E18/E16; IFI-4; OIAS; OIASI
Gene ID
4938
UniProt
P00973
Cellular Locus
Cytoplasm, Endoplasmic reticulum, Microsome, Mitochondrion, Nucleus, Secreted
Dilution
WB 1:500 - 1:2000
Form
Liquid
Buffer
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
Calculated MW: 41kDa/43kDa/46kDa/47kDa Observed MW: 46kDa
Storage Conditions
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Gene ID URL
https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4938
Uniprot URL
https://www.uniprot.org/uniprot/P00973
AA Sequence
MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKGGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQ
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