COX2/PTGS2 Rabbit pAb (APR19158N)
Product Specifications
Background
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.
Synonyms
PTGS2; COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2; Cox2
Gene ID
5743
UniProt
P35354
Cellular Locus
Endoplasmic reticulum membrane, Microsome membrane, Peripheral membrane protein
Applications
WB (Mouse embryonal fibroblast cell, RAW264.7, Mouse kidney, Mus musculus, Rattus norvegicus, Trifolium pratense, Schisandra chinensis, Homo sapiens, Gallus gallus) IHC (RAW264.7, Mouse kidney, Mus musculus, Rattus norvegicus) IF (Mus musculus, Homo sapiens)
Dilution
WB 1:1000 - 1:4000 IHC 1:50 - 1:200 IF 1:50 - 1:100
Form
Liquid
Buffer
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
Calculated MW: 68kDa Observed MW: 74KDa
Storage Conditions
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality COX2/PTGS2 Rabbit pAb (APR19158N) .
Gene ID URL
https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5743
Uniprot URL
https://www.uniprot.org/uniprot/P35354
AA Sequence
PLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEVGFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKERSTEL
Available Sizes
Curated Selection
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