TNF-α Rabbit pAb (APR18490N)
Product Specifications
Background
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TNF-α Rabbit pAb (APR18488N4) .
Synonyms
TNF; DIF; TNF-alpha; TNFA; TNFSF2; TNLG1F; TNF alpha
Gene ID
7124
UniProt
P01375
Cellular Locus
Cell membrane, Membrane, Secreted, Single-pass type II membrane protein, Single-pass type II membrane protein
Applications
IHC (Mouse breast cancer, Homo sapiens, Mus musculus, Rattus norvegicus) ChIP (Homo sapiens, Mus musculus) IF (Rattus norvegicus, Homo sapiens, Mus musculus) WB (Homo sapiens, quails, Mus musculus, Rattus norvegicus, Gallus gallus)
Dilution
WB 1:1000 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100
Form
Liquid
Buffer
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
Calculated MW: 25kDa Observed MW: 28KDa
Storage Conditions
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Gene ID URL
https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7124
Uniprot URL
https://www.uniprot.org/uniprot/P01375
AA Sequence
Email for sequence
Available Sizes
Frequently Asked Questions
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