TRIB1 Rabbit pAb (APR17764N)
Product Specifications
Background
Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase. The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain. Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA. Binds selectively the recognition sequence of CEBPA. Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity. Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity. Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity.
Synonyms
TRIB1; C8FW; GIG-2; GIG2; SKIP1; TRB-1; TRB1
Gene ID
10221
UniProt
Q96RU8
Dilution
WB 1:1000 - 1:4000
Form
Liquid
Buffer
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
Calculated MW: 23kDa/41kDa Observed MW: 38kDa
Storage Conditions
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TRIB1 Rabbit pAb (APR17764N) .
Gene ID URL
https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10221
Uniprot URL
https://www.uniprot.org/uniprot/Q96RU8
AA Sequence
LGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEPGYIDSEIGTSDQIVPEYQEDSDISSFFC
Available Sizes
Curated Selection
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