Mineralocorticoid receptor (NR3C2) Rabbit mAb (AMR11256N)
Product Specifications
Background
This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.
Synonyms
NR3C2; MCR; MLR; MR; NR3C2VIT
Gene ID
4306
UniProt
P08235
Cellular Locus
Cytoplasm, Endoplasmic reticulum membrane, Nucleus, Peripheral membrane protein
Dilution
WB 1:500 - 1:2000
Form
Liquid
Buffer
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
Calculated MW: 75kDa/94kDa/107kDa Observed MW: 100KDa
Storage Conditions
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Mineralocorticoid receptor (NR3C2) Rabbit mAb (APR24627N8) .
Gene ID URL
https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4306
Uniprot URL
https://www.uniprot.org/uniprot/P08235
AA Sequence
Email for sequence
Available Sizes
Curated Selection
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