Phospho-Chk1-S345 Rabbit pAb (AMR01006N)
Product Specifications
Background
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.
Synonyms
CHEK1; CHK1
Gene ID
1111
UniProt
O14757
Cellular Locus
Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center
Applications
WB (Human lung cancer cell, H460, Mus musculus, Homo sapiens)
Dilution
WB 1:500 - 1:2000
Form
Liquid
Buffer
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
Calculated MW: 43kDa/50kDa/54kDa Observed MW: 54kDa
Storage Conditions
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-Chk1-S345 Rabbit pAb (AMR01006N) .
Gene ID URL
https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1111
Uniprot URL
https://www.uniprot.org/uniprot/O14757
AA Sequence
SFSQP
Available Sizes
Curated Selection
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