Phospho-p53-S46 Rabbit pAb (AMR00929N)
Product Specifications
Background
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277) .
Synonyms
BCC7; LFS1; P53; TRP53; p53; TP53; BMFS5
Gene ID
7157
UniProt
P04637
Cellular Locus
Cytoplasm, Endoplasmic reticulum, Mitochondrion matrix, Nucleus, PML body
Dilution
WB 1:1000 - 1:2000 IP 1:50 - 1:100
Form
Liquid
Buffer
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
Calculated MW: 23-43kDa Observed MW: 53KDa
Storage Conditions
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-p53-S46 Rabbit pAb (AMR00929N) .
Gene ID URL
https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7157
Uniprot URL
https://www.uniprot.org/uniprot/P04637
AA Sequence
MLSPD
Available Sizes
Curated Selection
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