Phospho-MDM2-S166 Rabbit pAb (AMR00825N)
Product Specifications
Background
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-MDM2-S166 Rabbit pAb (AMR00825N) .
Synonyms
MDM2; ACTFS; HDMX; hdm2
Gene ID
4193
UniProt
Q00987
Cellular Locus
Cytoplasm, Nucleus, nucleolus, nucleoplasm
Applications
WB (Adenocarcinoma human alveolar basal epithelial cells) IHC (Adenocarcinoma human alveolar basal epithelial cells)
Dilution
WB 1:500 - 1:1000 IF 1:50 - 1:100
Form
Liquid
Buffer
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
Calculated MW: 11-14kDa/24-55kDa Observed MW: 95kDa
Storage Conditions
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Gene ID URL
https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4193
Uniprot URL
https://www.uniprot.org/uniprot/Q00987
AA Sequence
TSSRR
Available Sizes
Frequently Asked Questions
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