GAPDH Mouse mAb (AMM22048N)
Product Specifications
Background
This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD) . The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants.
Synonyms
G3PD; GAPD; HEL-S-162eP; GAPDH
Gene ID
2597
UniProt
P04406
Cellular Locus
Cytoplasm, Membrane, Nucleus, cytoskeleton, cytosol, perinuclear region
Applications
WB (Arabidopsis thaliana, Mus musculus, Homo sapiens, Zika virus, Other, Sus scrofa, Rattus norvegicus, Nicotiana tabacum L., Capra hircus, fenugreek, Gallus gallus, Ctenopharyngodon idellus, Danio rerio, Yeast, Fenneropenaeus chinensis, Giardia duodenalis, Chlorocebus sabaeus) IHC (Mus musculus) IF (Homo sapiens, Mus musculus) Co-IP (Homo sapiens) IP (Homo sapiens) ELISA (Ctenopharyngodon idellus)
Dilution
WB 1:5000 - 1:20000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Form
Liquid
Buffer
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
Calculated MW: 31kDa/36kDa Observed MW: 36KDa
Storage Conditions
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality GAPDH Mouse mAb (AMM22048N) .
Gene ID URL
https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2597
Uniprot URL
https://www.uniprot.org/uniprot/P04406
AA Sequence
Email for sequence
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
