PLOD2 Mouse Monoclonal Antibody [Clone ID: LBI7G5]

Product Specifications

Background

The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Overview

Carrier-free (BSA/glycerol-free) PLOD2 mouse monoclonal antibody, clone LBI7G5

Synonyms

BRKS2; LH2; TLH

Gene Name

Homo sapiens procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2), transcript variant 1, mRNA.

Gene ID

5352

UniProt

O00469

Conjugation

Unconjugated

Related Pathways

Lysine degradation

Field of Research

Lysine degradation

Dilution

WB 1:2000, IHC 1:150

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.