Melanoma gp100 (PMEL) Mouse Monoclonal Antibody [Clone ID: LBI6D5]
Product Specifications
Background
This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan
Synonyms
D12S53E; gp100; ME20; ME20-M; ME20M; P1; P100; PMEL17; SI; SIL; SILV
Gene Name
Homo sapiens premelanosome protein (PMEL), transcript variant 3, mRNA.
Gene ID
6490
UniProt
P40967
Conjugation
Unconjugated
Dilution
WB 1:2000
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Function
Secreted Protein, Transmembrane
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
PMEL
Overview
Carrier-free (BSA/glycerol-free) SILV mouse monoclonal antibody, clone LBI6D5
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=6490
Uniprot URL
https://www.uniprot.org/uniprot/P40967
Curated Selection
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