DDIT3 Mouse Monoclonal Antibody [Clone ID: LBI3H7]

Product Specifications

Background

This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]

Overview

Carrier-free (BSA/glycerol-free) DDIT3 mouse monoclonal antibody, clone LBI3H7

Synonyms

CEBPZ; CHOP; CHOP-10; CHOP10; GADD153

Gene Name

Homo sapiens DNA damage inducible transcript 3 (DDIT3), transcript variant 5, mRNA.

Gene ID

1649

UniProt

P35638

Conjugation

Unconjugated

Related Pathways

MAPK signaling pathway

Field of Research

MAPK signaling pathway

Dilution

WB 1:2000

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome, Transcription Factors

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.