Thymidylate Synthase (TYMS) Mouse Monoclonal Antibody [Clone ID: LBI1E12]
Product Specifications
Background
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008]
Synonyms
HST422; TMS; TS
Gene Name
Homo sapiens thymidylate synthetase (TYMS), transcript variant 1, mRNA.
Gene ID
7298
UniProt
P04818
Conjugation
Unconjugated
Related Pathways
Metabolic pathways, One carbon pool by folate, Pyrimidine metabolism
Field of Research
Metabolic pathways, One carbon pool by folate, Pyrimidine metabolism
Dilution
WB 1:2000
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Function
Druggable Genome
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
TYMS
Overview
Carrier-free (BSA/glycerol-free) TYMS mouse monoclonal antibody, clone LBI1E12
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=7298
Uniprot URL
https://www.uniprot.org/uniprot/P04818
Curated Selection
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