Thymidylate Synthase (TYMS) Mouse Monoclonal Antibody [Clone ID: LBI5H8]

Product Specifications

Background

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008]

Overview

Carrier-free (BSA/glycerol-free) TYMS mouse monoclonal antibody, clone LBI5H8

Synonyms

HST422; TMS; TS

Gene Name

Homo sapiens thymidylate synthetase (TYMS), transcript variant 1, mRNA.

Gene ID

7298

UniProt

P04818

Conjugation

Unconjugated

Related Pathways

Metabolic pathways, One carbon pool by folate, Pyrimidine metabolism

Field of Research

Metabolic pathways, One carbon pool by folate, Pyrimidine metabolism

Dilution

WB 1:2000, IHC 1:150

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.