RASGRP3 Mouse Monoclonal Antibody [Clone ID: LBI2G7]

Product Specifications

Background

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]) . [supplied by OMIM, Mar 2008]

Overview

Carrier-free (BSA/glycerol-free) RASGRP3 mouse monoclonal antibody, clone LBI2G7

Synonyms

GRP3

Gene Name

Homo sapiens RAS guanyl releasing protein 3 (RASGRP3), transcript variant 2, mRNA.

Gene ID

25780

UniProt

Q8IV61

Conjugation

Unconjugated

Related Pathways

B cell receptor signaling pathway, MAPK signaling pathway

Field of Research

B cell receptor signaling pathway, MAPK signaling pathway

Dilution

WB 1:2000, IHC 1:150

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.