Neurofilament (NEFL) Mouse Monoclonal Antibody [Clone ID: LBI2F5]

Product Specifications

Background

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008]

Overview

Carrier-free (BSA/glycerol-free) NEFL mouse monoclonal antibody, clone LBI2F5

Synonyms

CMT1F; CMT2E; NF-L; NF68; NFL; PPP1R110

Gene Name

Homo sapiens neurofilament light chain (NEFL), mRNA.

Gene ID

4747

UniProt

P07196

Conjugation

Unconjugated

Related Pathways

Amyotrophic lateral sclerosis (ALS)

Field of Research

Amyotrophic lateral sclerosis (ALS)

Dilution

WB 1:2000

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome, ES Cell Differentiation/IPS

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.