RRM1 Mouse Monoclonal Antibody [Clone ID: LBI5G5]

Product Specifications

Background

This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. [provided by RefSeq, Jul 2008]

Overview

Carrier-free (BSA/glycerol-free) RRM1 mouse monoclonal antibody, clone LBI5G5

Synonyms

R1; RIR1; RR1

Gene Name

Homo sapiens ribonucleotide reductase catalytic subunit M1 (RRM1), transcript variant 1, mRNA.

Gene ID

6240

UniProt

P23921

Conjugation

Unconjugated

Related Pathways

Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism

Field of Research

Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism

Dilution

WB 1:2000, IHC 1:150

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.