P Glycoprotein (ABCB1) Mouse Monoclonal Antibody [Clone ID: LBI3C8]

Product Specifications

Background

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]

Overview

Carrier-free (glycerol/BSA-free) Purified ABCB1 mouse monoclonal antibody, clone LBI3C8

Synonyms

ABC20; CD243; CLCS; GP170; MDR1; p-170; P-GP; PGY1

Gene Name

Homo sapiens ATP binding cassette subfamily B member 1 (ABCB1), transcript variant 3, mRNA.

Gene ID

5243

UniProt

P08183

Conjugation

Unconjugated

Related Pathways

ABC transporters

Field of Research

ABC transporters

Dilution

IHC 1:150

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome, ES Cell Differentiation/IPS, Transmembrane

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.