BCL10 Mouse Monoclonal Antibody [Clone ID: LBI9C2]

Product Specifications

Background

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008]

Overview

Carrier-free (BSA/glycerol-free) BCL10 mouse monoclonal antibody, clone LBI9C2

Synonyms

C-E10; CARMEN; CIPER; CLAP; IMD37; mE10

Gene Name

Homo sapiens BCL10 immune signaling adaptor (BCL10), transcript variant 1, mRNA.

Gene ID

8915

UniProt

O95999

Conjugation

Unconjugated

Related Pathways

B cell receptor signaling pathway, T cell receptor signaling pathway

Field of Research

B cell receptor signaling pathway, T cell receptor signaling pathway

Dilution

WB 1:2000, IHC 1:150

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.