APE1 (APEX1) Mouse Monoclonal Antibody [Clone ID: LBI2A4]
Product Specifications
Background
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq]
Synonyms
APE; APE1; APEN; APEX; APX; HAP1; REF1
Gene Name
Homo sapiens apurinic/apyrimidinic endodeoxyribonuclease 1 (APEX1), transcript variant 1, mRNA.
Gene ID
328
UniProt
P27695
Conjugation
Unconjugated
Related Pathways
Base excision repair
Field of Research
Base excision repair
Dilution
WB 1:2000, IHC 1:150, IF 1:100, FLOW 1:100
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Function
Druggable Genome, Stem cell - Pluripotency, Transcription Factors
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
APEX1
Overview
Carrier-free (BSA/glycerol-free) APEX1 mouse monoclonal antibody, clone LBI2A4
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=328
Uniprot URL
https://www.uniprot.org/uniprot/P27695
Curated Selection
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