TMS1 (PYCARD) Mouse Monoclonal Antibody [Clone ID: LBI1H6]

Product Specifications

Background

This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD) . The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Overview

Carrier-free (BSA/glycerol-free) PYCARD mouse monoclonal antibody, clone LBI1H6

Synonyms

ASC; CARD5; TMS; TMS-1; TMS1

Gene Name

Homo sapiens PYD and CARD domain containing (PYCARD), transcript variant 1, mRNA.

Gene ID

29108

UniProt

Q9ULZ3

Conjugation

Unconjugated

Related Pathways

Cytosolic DNA-sensing pathway, NOD-like receptor signaling pathway

Field of Research

Cytosolic DNA-sensing pathway, NOD-like receptor signaling pathway

Dilution

WB 1:2000, FLOW 1:100

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.