TMS1 (PYCARD) Mouse Monoclonal Antibody [Clone ID: LBI3E9]
Product Specifications
Background
This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD) . The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Synonyms
ASC; CARD5; TMS; TMS-1; TMS1
Gene Name
Homo sapiens PYD and CARD domain containing (PYCARD), transcript variant 1, mRNA.
Gene ID
29108
UniProt
Q9ULZ3
Conjugation
Unconjugated
Related Pathways
Cytosolic DNA-sensing pathway, NOD-like receptor signaling pathway
Field of Research
Cytosolic DNA-sensing pathway, NOD-like receptor signaling pathway
Dilution
WB 1:500~2000, IHC 1:150, FLOW 1:100
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Function
Druggable Genome
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
PYCARD
Overview
Carrier-free (BSA/glycerol-free) PYCARD mouse monoclonal antibody, clone LBI3E9
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=29108
Uniprot URL
https://www.uniprot.org/uniprot/Q9ULZ3
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
