IL1 Receptor II (IL1R2) Mouse Monoclonal Antibody [Clone ID: LBI3C6]

Product Specifications

Background

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]

Overview

Carrier-free (BSA/glycerol-free) IL1R2 mouse monoclonal antibody, clone LBI3C6

Synonyms

CD121b; CDw121b; IL-1R-2; IL-1RT-2; IL-1RT2; IL1R2c; IL1RB

Gene Name

Homo sapiens interleukin 1 receptor type 2 (IL1R2), transcript variant 1, mRNA.

Gene ID

7850

UniProt

P27930

Conjugation

Unconjugated

Related Pathways

Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, MAPK signaling pathway

Field of Research

Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, MAPK signaling pathway

Dilution

WB 1:1000

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome, Transmembrane

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.