PIK3C2B Mouse Monoclonal Antibody [Clone ID: LBI2G3]

Product Specifications

Background

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]

Overview

Carrier-free (BSA/glycerol-free) PIK3C2B mouse monoclonal antibody, clone LBI2G3

Synonyms

C2-PI3K

Gene Name

Homo sapiens phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta (PIK3C2B), transcript variant 2, mRNA.

Gene ID

5287

UniProt

O00750

Conjugation

Unconjugated

Related Pathways

Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system

Field of Research

Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system

Dilution

WB 1:2000~4000, IHC 1:150, IF 1:100

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.