Iduronate 2 sulfatase (IDS) Mouse Monoclonal Antibody [Clone ID: LBI1D9]
Product Specifications
Background
Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked Mucopolysaccharidosis Type II, also known as Hunter Syndrome. Iduronate-2-sulfatase has a strong sequence similarity with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq]
Synonyms
MPS2; SIDS
Gene Name
Homo sapiens iduronate 2-sulfatase (IDS), transcript variant 1, mRNA.
Gene ID
3423
UniProt
P22304
Conjugation
Unconjugated
Related Pathways
Glycosaminoglycan degradation, Lysosome, Metabolic pathways
Field of Research
Glycosaminoglycan degradation, Lysosome, Metabolic pathways
Dilution
WB 1:500~2000, IHC 1:150, IF 1:100, FLOW 1:100
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Function
Druggable Genome
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
IDS
Overview
Carrier-free (BSA/glycerol-free) IDS mouse monoclonal antibody, clone LBI1D9
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=3423
Uniprot URL
https://www.uniprot.org/uniprot/P22304
Curated Selection
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