PDE4 (PDE4B) Mouse Monoclonal Antibody [Clone ID: LBI1D12]

Product Specifications

Background

This gene is a member of the type IV, cyclic AMP (cAMP) -specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Overview

Carrier-free (BSA/glycerol-free) PDE4B mouse monoclonal antibody, clone LBI1D12

Synonyms

DPDE4; PDE4B5; PDEIVB

Gene Name

Homo sapiens phosphodiesterase 4B (PDE4B), transcript variant a, mRNA.

Gene ID

5142

UniProt

Q07343

Conjugation

Unconjugated

Related Pathways

Progesterone-mediated oocyte maturation, Purine metabolism

Field of Research

Progesterone-mediated oocyte maturation, Purine metabolism

Dilution

WB 1:500~2000, IHC 1:150, IF 1:100, FLOW 1:100

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.