PDE4 (PDE4B) Mouse Monoclonal Antibody [Clone ID: LBI1D12]
Product Specifications
Background
This gene is a member of the type IV, cyclic AMP (cAMP) -specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Synonyms
DPDE4; PDE4B5; PDEIVB
Gene Name
Homo sapiens phosphodiesterase 4B (PDE4B), transcript variant a, mRNA.
Gene ID
5142
UniProt
Q07343
Conjugation
Unconjugated
Related Pathways
Progesterone-mediated oocyte maturation, Purine metabolism
Field of Research
Progesterone-mediated oocyte maturation, Purine metabolism
Dilution
WB 1:500~2000, IHC 1:150, IF 1:100, FLOW 1:100
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Function
Druggable Genome
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
PDE4B
Overview
Carrier-free (BSA/glycerol-free) PDE4B mouse monoclonal antibody, clone LBI1D12
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=5142
Uniprot URL
https://www.uniprot.org/uniprot/Q07343
Curated Selection
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