CCM2 Mouse Monoclonal Antibody [Clone ID: LBI1E9]

Product Specifications

Background

This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.

Overview

Carrier-free (BSA/glycerol-free) CCM2 mouse monoclonal antibody, clone LBI1E9

Synonyms

C7orf22; OSM; PP10187

Gene Name

Homo sapiens CCM2 scaffold protein (CCM2), transcript variant 2, mRNA.

Gene ID

83605

UniProt

Q9BSQ5

Conjugation

Unconjugated

Dilution

WB 1:500~2000, IHC 1:150

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.