PANK2 Mouse Monoclonal Antibody [Clone ID: LBI4B3]

Product Specifications

Background

This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms. [provided by RefSeq]

Overview

Carrier-free (BSA/glycerol-free) PANK2 mouse monoclonal antibody, clone LBI4B3

Synonyms

C20orf48; HARP; HSS; NBIA1; PKAN

Gene Name

Homo sapiens pantothenate kinase 2 (PANK2), transcript variant 1, mRNA; nuclear gene for mitochondrial product.

Gene ID

80025

UniProt

Q9BZ23

Conjugation

Unconjugated

Related Pathways

Metabolic pathways, Pantothenate and CoA biosynthesis

Field of Research

Metabolic pathways, Pantothenate and CoA biosynthesis

Dilution

WB 1:2000, IHC 1:150, IF 1:100

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.