TPMT Mouse Monoclonal Antibody [Clone ID: LBI2A2]
Product Specifications
Background
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q.
Synonyms
OTTHUMP00000016076; S-adenosyl-L-methionine:thiopurine S-methyltransferase; thiopurine methyltransferase; thiopurine S-methyltransferase
Gene Name
Homo sapiens thiopurine S-methyltransferase (TPMT), transcript variant 1, mRNA.
Gene ID
7172
UniProt
P51580
Conjugation
Unconjugated
Related Pathways
Drug metabolism - other enzymes
Field of Research
Drug metabolism - other enzymes
Dilution
WB 1:1000, IHC 1:50, IF 1:100
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Function
Druggable Genome
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
TPMT
Overview
Carrier-free (BSA/glycerol-free) TPMT mouse monoclonal antibody, clone LBI2A2
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=7172
Uniprot URL
https://www.uniprot.org/uniprot/P51580
Curated Selection
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