TPMT Mouse Monoclonal Antibody [Clone ID: LBI2A2]

Product Specifications

Background

This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q.

Overview

Carrier-free (BSA/glycerol-free) TPMT mouse monoclonal antibody, clone LBI2A2

Synonyms

OTTHUMP00000016076; S-adenosyl-L-methionine:thiopurine S-methyltransferase; thiopurine methyltransferase; thiopurine S-methyltransferase

Gene Name

Homo sapiens thiopurine S-methyltransferase (TPMT), transcript variant 1, mRNA.

Gene ID

7172

UniProt

P51580

Conjugation

Unconjugated

Related Pathways

Drug metabolism - other enzymes

Field of Research

Drug metabolism - other enzymes

Dilution

WB 1:1000, IHC 1:50, IF 1:100

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.