HIPPI (IFT57) Mouse Monoclonal Antibody [Clone ID: LBI2G3]

Product Specifications

Background

Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity) . Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3'present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear

Overview

Carrier-free (BSA/glycerol-free) IFT57 mouse monoclonal antibody, clone LBI2G3

Synonyms

ESRRBL1; HIPPI; MHS4R2

Gene Name

Homo sapiens intraflagellar transport 57 (IFT57), mRNA.

Gene ID

55081

UniProt

Q9NWB7

Conjugation

Unconjugated

Related Pathways

Huntington's disease

Field of Research

Huntington's disease

Dilution

WB 1:1000, IHC 1:50, IF 1:100

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.