HIPPI (IFT57) Mouse Monoclonal Antibody [Clone ID: LBI2G3]
Product Specifications
Background
Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity) . Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3'present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear
Synonyms
ESRRBL1; HIPPI; MHS4R2
Gene Name
Homo sapiens intraflagellar transport 57 (IFT57), mRNA.
Gene ID
55081
UniProt
Q9NWB7
Conjugation
Unconjugated
Related Pathways
Huntington's disease
Field of Research
Huntington's disease
Dilution
WB 1:1000, IHC 1:50, IF 1:100
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Function
Druggable Genome
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
IFT57
Overview
Carrier-free (BSA/glycerol-free) IFT57 mouse monoclonal antibody, clone LBI2G3
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=55081
Uniprot URL
https://www.uniprot.org/uniprot/Q9NWB7
Curated Selection
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