Livin (BIRC7) Mouse Monoclonal Antibody [Clone ID: LBI1B10]

Product Specifications

Background

The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide.

Overview

Carrier-free (BSA/glycerol-free) BIRC7 mouse monoclonal antibody, clone LBI1B10

Synonyms

KIAP; LIVIN; ML-IAP; MLIAP; RNF50

Gene Name

Homo sapiens baculoviral IAP repeat containing 7 (BIRC7), transcript variant 1, mRNA.

Gene ID

79444

UniProt

Q96CA5

Conjugation

Unconjugated

Dilution

WB 1:2000, IF 1:100, Flow 1:100

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.