TrkC (NTRK3) Mouse Monoclonal Antibody [Clone ID: LBI2B8]

Product Specifications

Background

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.

Overview

Carrier-free (BSA/glycerol-free) NTRK3 mouse monoclonal antibody, clone LBI2B8

Synonyms

Gp145 (trkC) ; GP145-TrkC; TRKC; gp145 (trkC)

Gene Name

Homo sapiens neurotrophic receptor tyrosine kinase 3 (NTRK3), transcript variant 3, mRNA.

Gene ID

4916

UniProt

Q16288

Conjugation

Unconjugated

Related Pathways

Neurotrophin signaling pathway

Field of Research

Neurotrophin signaling pathway

Dilution

WB 1:2000, IHC 1:50, IF 1:100

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome, Protein Kinase, Transmembrane

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.