TrkC (NTRK3) Mouse Monoclonal Antibody [Clone ID: LBI2B8]
Product Specifications
Background
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.
Synonyms
Gp145 (trkC) ; GP145-TrkC; TRKC; gp145 (trkC)
Gene Name
Homo sapiens neurotrophic receptor tyrosine kinase 3 (NTRK3), transcript variant 3, mRNA.
Gene ID
4916
UniProt
Q16288
Conjugation
Unconjugated
Related Pathways
Neurotrophin signaling pathway
Field of Research
Neurotrophin signaling pathway
Dilution
WB 1:2000, IHC 1:50, IF 1:100
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Function
Druggable Genome, Protein Kinase, Transmembrane
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
NTRK3
Overview
Carrier-free (BSA/glycerol-free) NTRK3 mouse monoclonal antibody, clone LBI2B8
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=4916
Uniprot URL
https://www.uniprot.org/uniprot/Q16288
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