TrkB (NTRK2) Mouse Monoclonal Antibody [Clone ID: LBI2E1]

Product Specifications

Background

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene

Overview

Carrier-free (BSA/glycerol-free) NTRK2 mouse monoclonal antibody, clone LBI2E1

Synonyms

GP145-TrkB; OBHD; trk-B; TRKB

Gene Name

Homo sapiens neurotrophic receptor tyrosine kinase 2 (NTRK2), transcript variant b, mRNA.

Gene ID

4915

UniProt

Q16620

Conjugation

Unconjugated

Related Pathways

MAPK signaling pathway, Neurotrophin signaling pathway

Field of Research

MAPK signaling pathway, Neurotrophin signaling pathway

Dilution

WB 1:1000, IHC 1:150, IF 1:100

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome, Protein Kinase, Transmembrane

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.