PCNA Mouse Monoclonal Antibody [Clone ID: UMLBI278]
Product Specifications
Background
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]
Synonyms
ATLD2
Gene Name
Homo sapiens proliferating cell nuclear antigen (PCNA), transcript variant 1, mRNA.
Gene ID
5111
UniProt
P12004
Conjugation
Unconjugated
Related Pathways
Base excision repair, Cell cycle, DNA replication, Mismatch repair, Nucleotide excision repair
Field of Research
Base excision repair, Cell cycle, DNA replication, Mismatch repair, Nucleotide excision repair
Dilution
IHC 1:4000
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Function
Druggable Genome, Stem cell - Pluripotency
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
PCNA
Overview
Carrier-free (BSA/glycerol-free) PCNA mouse monoclonal antibody, clone UMLBI278
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=5111
Uniprot URL
https://www.uniprot.org/uniprot/P12004
Curated Selection
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