MSH2 Mouse Monoclonal Antibody [Clone ID: UMLBI259]

Product Specifications

Background

This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC) . When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Overview

Carrier-free (BSA/glycerol-free) MSH2 mouse monoclonal antibody, clone UMLBI259

Synonyms

COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2; MMRCS2

Gene Name

Homo sapiens mutS homolog 2 (MSH2), transcript variant 1, mRNA.

Gene ID

4436

UniProt

P43246

Conjugation

Unconjugated

Related Pathways

Colorectal cancer, Mismatch repair, Pathways in cancer

Field of Research

Colorectal cancer, Mismatch repair, Pathways in cancer

Dilution

IHC 1:2400

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome, Stem cell - Pluripotency

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.