JAK3 Mouse Monoclonal Antibody [Clone ID: LBI2B4]

Product Specifications

Background

The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease) . [provided by RefSeq, Jul 2008]

Overview

Carrier-free (BSA/glycerol-free) JAK3 mouse monoclonal antibody, clone LBI2B4

Synonyms

JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK

Gene Name

Homo sapiens Janus kinase 3 (JAK3), mRNA.

Gene ID

3718

UniProt

P52333

Conjugation

Unconjugated

Related Pathways

Chemokine signaling pathway, Jak-STAT signaling pathway, Primary immunodeficiency

Field of Research

Chemokine signaling pathway, Jak-STAT signaling pathway, Primary immunodeficiency

Dilution

WB 1:500

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome, Protein Kinase

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.