Cathepsin L (CTSL) Mouse Monoclonal Antibody [Clone ID: LBI5C8]

Product Specifications

Background

The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]

Overview

Carrier-free (BSA/glycerol-free) CTSL mouse monoclonal antibody, clone LBI5C8

Synonyms

CATL; CTSL1; MEP

Gene Name

Homo sapiens cathepsin L (CTSL), transcript variant 1, mRNA.

Gene ID

1514

UniProt

P07711

Conjugation

Unconjugated

Related Pathways

Antigen processing and presentation, Lysosome

Field of Research

Antigen processing and presentation, Lysosome

Dilution

WB 1:500, IHC 1:500

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome, Protease

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.