CAD Mouse Monoclonal Antibody [Clone ID: LBI1A7]
Product Specifications
Background
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Synonyms
CDG1Z; DEE50; EIEE50; GATD4
Gene Name
Homo sapiens carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD), transcript variant 1, mRNA.
Gene ID
790
UniProt
P27708
Conjugation
Unconjugated
Related Pathways
Alanine, aspartate and glutamate metabolism, Metabolic pathways, Pyrimidine metabolism
Field of Research
Alanine, aspartate and glutamate metabolism, Metabolic pathways, Pyrimidine metabolism
Dilution
WB 1:250~500
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Function
Druggable Genome
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
CAD
Overview
Carrier-free (BSA/glycerol-free) CAD mouse monoclonal antibody, clone LBI1A7
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=790
Uniprot URL
https://www.uniprot.org/uniprot/P27708
Curated Selection
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