CAD Mouse Monoclonal Antibody [Clone ID: LBI1A7]

Product Specifications

Background

The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Overview

Carrier-free (BSA/glycerol-free) CAD mouse monoclonal antibody, clone LBI1A7

Synonyms

CDG1Z; DEE50; EIEE50; GATD4

Gene Name

Homo sapiens carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD), transcript variant 1, mRNA.

Gene ID

790

UniProt

P27708

Conjugation

Unconjugated

Related Pathways

Alanine, aspartate and glutamate metabolism, Metabolic pathways, Pyrimidine metabolism

Field of Research

Alanine, aspartate and glutamate metabolism, Metabolic pathways, Pyrimidine metabolism

Dilution

WB 1:250~500

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.