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MTHFR Mouse Monoclonal Antibody [Clone ID: LBI2B4]

Product Specifications

Background

The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency. [provided by RefSeq, Oct 2009]

Synonyms

5,10-methylenetetrahydrofolate reductase (NADPH) ; methylenetetrahydrofolate reductase intermediate form; OTTHUMP00000002367; OTTHUMP00000002368

Gene Name

Homo sapiens methylenetetrahydrofolate reductase (MTHFR), transcript variant 2, mRNA.

Gene ID

4524

UniProt

P42898

Conjugation

Unconjugated

Related Pathways

Metabolic pathways, Methane metabolism, One carbon pool by folate

Field of Research

Metabolic pathways, Methane metabolism, One carbon pool by folate

Dilution

WB 1:500

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Symbol

MTHFR

Overview

Carrier-free (BSA/glycerol-free) MTHFR mouse monoclonal antibody, clone LBI2B4

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/?term=4524

Uniprot URL

https://www.uniprot.org/uniprot/P42898

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