UAP56 (DDX39B) Mouse Monoclonal Antibody [Clone ID: LBI2G7]
Product Specifications
Background
Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [PubMed:23299939] reporting a stimulatory effect. [UniProtKB/Swiss-Prot Function]
Synonyms
BAT1; D6S81E; UAP56
Gene Name
Homo sapiens DExD-box helicase 39B (DDX39B), transcript variant 1, mRNA.
Gene ID
7919
UniProt
Q13838
Conjugation
Unconjugated
Related Pathways
Spliceosome
Field of Research
Spliceosome
Dilution
WB 1:500, IHC 1:500
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
DDX39B
Overview
Carrier-free (BSA/glycerol-free) DDX39B mouse monoclonal antibody, clone LBI2G7
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=7919
Uniprot URL
https://www.uniprot.org/uniprot/Q13838
Curated Selection
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