NEDD4 Mouse Monoclonal Antibody [Clone ID: LBI7A1]
Product Specifications
Background
This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016]
Synonyms
NEDD4-1; RPF1
Gene Name
Homo sapiens NEDD4 E3 ubiquitin protein ligase (NEDD4), transcript variant 2, mRNA.
Gene ID
4734
UniProt
P46934
Conjugation
Unconjugated
Related Pathways
Endocytosis, Ubiquitin mediated proteolysis
Field of Research
Endocytosis, Ubiquitin mediated proteolysis
Dilution
WB 1:500
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Function
Druggable Genome
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
NEDD4
Overview
Carrier-free (BSA/glycerol-free) NEDD4 mouse monoclonal antibody, clone LBI7A1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=4734
Uniprot URL
https://www.uniprot.org/uniprot/P46934
Curated Selection
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