Beta Arrestin 1 (ARRB1) Mouse Monoclonal Antibody [Clone ID: LBI3G9]

Product Specifications

Background

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011].

Overview

Carrier-free (BSA/glycerol-free) ARRB1 mouse monoclonal antibody, clone LBI3G9

Synonyms

ARB1; ARR1

Gene Name

Homo sapiens arrestin beta 1 (ARRB1), transcript variant 1, mRNA.

Gene ID

408

UniProt

P49407

Conjugation

Unconjugated

Related Pathways

Chemokine signaling pathway, Endocytosis, MAPK signaling pathway

Field of Research

Chemokine signaling pathway, Endocytosis, MAPK signaling pathway

Dilution

WB 1:500

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.