MLH1 Mouse Monoclonal Antibody [Clone ID: LBI2D12]
Product Specifications
Background
This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC) . It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined. [provided by RefSeq, Nov 2009]
Overview
Carrier-free (BSA/glycerol-free) MLH1 mouse monoclonal antibody, clone LBI2D12
Synonyms
COCA2; FCC2; hMLH1; HNPCC; HNPCC2; MMRCS1
Gene Name
Homo sapiens mutL homolog 1 (MLH1), transcript variant 1, mRNA.
Gene ID
4292
UniProt
P40692
Conjugation
Unconjugated
Related Pathways
Colorectal cancer, Endometrial cancer, Mismatch repair, Pathways in cancer
Field of Research
Colorectal cancer, Endometrial cancer, Mismatch repair, Pathways in cancer
Dilution
WB 1:2000
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Function
Druggable Genome
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
MLH1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=4292
Uniprot URL
https://www.uniprot.org/uniprot/P40692
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