Bile Acid Receptor (NR1H4) Mouse Monoclonal Antibody [Clone ID: LBI4F12]

Product Specifications

Background

This gene encodes a ligand-activated transcription factor, which shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Overview

Carrier-free (BSA/glycerol-free) NR1H4 mouse monoclonal antibody, clone LBI4F12

Synonyms

BAR; FXR; HRR-1; HRR1; PFIC5; RIP14

Gene Name

Homo sapiens nuclear receptor subfamily 1 group H member 4 (NR1H4), transcript variant 2, mRNA.

Gene ID

9971

UniProt

Q96RI1

Conjugation

Unconjugated

Dilution

WB 1:2000, IHC 1:150

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome, Nuclear Hormone Receptor, Transcription Factors

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.