MGMT Mouse Monoclonal Antibody [Clone ID: LBI5A7]
Product Specifications
Background
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. [UniProtKB/Swiss-Prot Function]
Synonyms
Methylguanine-DNA methyltransferase; O-6-methylguanine-DNA methyltransferase; O6-methylguanine-DNA methyltransferase; OTTHUMP00000020741
Gene Name
Homo sapiens O-6-methylguanine-DNA methyltransferase (MGMT), mRNA.
Gene ID
4255
UniProt
P16455
Conjugation
Unconjugated
Dilution
WB 1:2000, IHC 1:150
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Function
Druggable Genome
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
MGMT
Overview
Carrier-free (BSA/glycerol-free) MGMT mouse monoclonal antibody, clone LBI5A7
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=4255
Uniprot URL
https://www.uniprot.org/uniprot/P16455
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